PDB entry 4kao

View 4kao on RCSB PDB site
Description: FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea
Class: Transferase/Transferase Inhibitor
Keywords: TYROSINE PROTEIN KINASE, TRANSFERASE,ATP BINDING, Transferase-Transferase Inhibitor complex
Deposited on 2013-04-22, released 2013-09-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-10-09, with a file datestamp of 2013-10-04.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: 0.183
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kaoa_
  • Chain 'B':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kaob_
  • Heterogens: KAO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kaoA (A:)
    gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
    flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
    yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
    wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
    pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kaoA (A:)
    yeiqrerielgrcigegqfgdvhqgiymspalavaiktcknctsdsvrekflqealtmrq
    fdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstalayl
    eskrfvhrdiaarnvlvssndcvklgdfglpikwmapesinfrrftsasdvwmfgvcmwe
    ilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprftelka
    qlstileeekaq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kaoB (B:)
    gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
    flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
    yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
    wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
    pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kaoB (B:)
    dyeiqrerielgrcigegqfgdvhqgiymsppalavaiktcknctsdsvrekflqealtm
    rqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstala
    yleskrfvhrdiaarnvlvssndcvklgdfglpikwmapesinfrrftsasdvwmfgvcm
    weilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprftel
    kaqlstileeekaq