SCOPe 2.08: Domain d4i4ba1: 4i4b A:3-110,A:221-421

Lineage for d4i4ba1 (4i4b A:3-110,A:221-421)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Pseudomonas mevalonii [TaxId:32044] [56546] (11 PDB entries)
   Uniprot P13702 4-377

8. Domain d4i4ba1: 4i4b A:3-110,A:221-421 [222895]
   Other proteins in same PDB: d4i4ba2, d4i4bb2
   automated match to d1qaxa2
   complexed with 1co, 1cv, gol, nad, so4

Details for d4i4ba1

PDB Entry: 4i4b, 1.7 Å

PDB Description: hmg-coa reductase from pseudomonas mevalonii complexed with nad and intermediate hemiacetal form of hmg-coa

PDB Compounds: (A:) 3-hydroxy-3-methylglutaryl-coenzyme A reductase

SCOPe Domain Sequences for d4i4ba1:

Sequence, based on SEQRES records:

>d4i4ba1 d.179.1.1 (A:3-110,A:221-421) Substrate-binding domain of HMG-CoA reductase {Pseudomonas mevalonii [TaxId: 32044]}
ldsrlpafrnlspaarldhigqllglshddvsllanagalpmdiangmienvigtfelpy
avasnfqingrdvlvplvveepsivaaasymaklaranggfttsssapXrlaraqvritp
qqletaefsgeaviegildayafaavdpyraathnkgimngidplivatgndwraveaga
hayacrsghygslttwekdnnghlvgtlempmpvglvggatkthplaqlslrilgvktaq
alaeiavavglaqnlgamralategiqrghmalharniavvagargdevdwvarqlveyh
dvradraval

Sequence, based on observed residues (ATOM records):

>d4i4ba1 d.179.1.1 (A:3-110,A:221-421) Substrate-binding domain of HMG-CoA reductase {Pseudomonas mevalonii [TaxId: 32044]}
ldsrlpafrnlspaarldhigqllglshddvsllanagalpmdiangmienvigtfelpy
avasnfqingrdvlvplvveepsivaaasymaklaranggfttsssapXrlaraqvritp
qqletaefsgeaviegildayafaavdpyraathnkgimngidplivatgndwraveaga
hayacrsghygslttwekdnnghlvgtlempmpvglvggatkthplaqlslrilgvktaq
alaeiavavglaqnlgamralategiqrghmalharniavvagarqlveyhdvradrava
l

Timeline for d4i4ba1:

• d4i4ba1 first appeared in SCOPe 2.03
  
• d4i4ba1 appears in SCOPe 2.07