SCOPe 2.07: Domain d4gj5b_: 4gj5 B:

Lineage for d4gj5b_ (4gj5 B:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)

8. Domain d4gj5b_: 4gj5 B: [221938]
   automated match to d2v0zc_
   complexed with 0lr, nag

Details for d4gj5b_

PDB Entry: 4gj5, 2.4 Å

PDB Description: crystal structure of renin in complex with nvp-amq838 (compound 5)

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d4gj5b_:

Sequence, based on SEQRES records:

>d4gj5b_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d4gj5b_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcstacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdlggqivlggsdpqhyegn
fhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgak
krlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipppt
gptwalgatfirkfytefdrrnnrigfalar

Timeline for d4gj5b_:

• d4gj5b_ first appeared in SCOPe 2.03
  
• d4gj5b_ appears in SCOPe 2.06
  
• d4gj5b_ appears in the current release, SCOPe 2.08