SCOPe 2.08: Domain d4dsua1: 4dsu A:2-180

Lineage for d4dsua1 (4dsu A:2-180)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (81 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein automated matches [190047] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186768] (291 PDB entries)

8. Domain d4dsua1: 4dsu A:2-180 [220001]
   Other proteins in same PDB: d4dsua2
   automated match to d3gftb_
   complexed with bzi, gdp, mg

Details for d4dsua1

PDB Entry: 4dsu, 1.7 Å

PDB Description: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

PDB Compounds: (A:) GTPase KRas, isoform 2B

SCOPe Domain Sequences for d4dsua1:

Sequence, based on SEQRES records:

>d4dsua1 c.37.1.8 (A:2-180) automated matches {Human (Homo sapiens) [TaxId: 9606]}
teyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtagq
eeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkkk

Sequence, based on observed residues (ATOM records):

>d4dsua1 c.37.1.8 (A:2-180) automated matches {Human (Homo sapiens) [TaxId: 9606]}
teyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtagq
samrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrt
vdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkkk

Timeline for d4dsua1:

• d4dsua1 first appeared in SCOPe 2.03, called d4dsua_
  
• d4dsua1 appears in SCOPe 2.07