SCOPe 2.07: Domain d3ru1a_: 3ru1 A:

Lineage for d3ru1a_ (3ru1 A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3ru1a_: 3ru1 A: [216071]
   automated match to d1w50a_
   complexed with 3ru, gol, iod

Details for d3ru1a_

PDB Entry: 3ru1, 2.3 Å

PDB Description: Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-(cyclohexylmethyl)propanamide

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3ru1a_:

Sequence, based on SEQRES records:

>d3ru1a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d3ru1a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgasvggsmiiggidhslytgslw
ytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksik
aasstekfpdgfwlgeqlvcwqnifpvislylmgevtnqsfritilpqqylrpvedcykf
aisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldmedc
gyn

Timeline for d3ru1a_:

• d3ru1a_ first appeared in SCOPe 2.03
  
• d3ru1a_ appears in SCOPe 2.06
  
• d3ru1a_ appears in the current release, SCOPe 2.08