SCOPe 2.05: Domain d3gh2x_: 3gh2 X:

Lineage for d3gh2x_ (3gh2 X:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189245] (8 PDB entries)

8. Domain d3gh2x_: 3gh2 X: [210534]
   automated match to d2aaza_
   complexed with so4

Details for d3gh2x_

PDB Entry: 3gh2, 1.75 Å

PDB Description: replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability

PDB Compounds: (X:) Thymidylate synthase

SCOPe Domain Sequences for d3gh2x_:

Sequence, based on SEQRES records:

>d3gh2x_ d.117.1.1 (X:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstr
eegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprd
lplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpg
dfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt
ikme

Sequence, based on observed residues (ATOM records):

>d3gh2x_ d.117.1.1 (X:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfw
kgvleellwfikgstnakelrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdys
gqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyq
rsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqrepr
pfpklrilrkvekiddfkaedfqiegynphptikme

Timeline for d3gh2x_:

• d3gh2x_ first appeared in SCOPe 2.03
  
• d3gh2x_ appears in SCOPe 2.04
  
• d3gh2x_ appears in SCOPe 2.06
  
• d3gh2x_ appears in the current release, SCOPe 2.08