PDB entry 3gh2

View 3gh2 on RCSB PDB site
Description: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Class: transferase
Keywords: TRANSFERASE, Methyltransferase, Nucleotide biosynthesis
Deposited on 2009-03-02, released 2010-03-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.22
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: OK/SW-cl.29, TS, TYMS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3gh2x_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3gh2X (X:)
mpfagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3gh2X (X:)
elprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfw
kgvleellwfikgstnakelrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdys
gqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyq
rsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqrepr
pfpklrilrkvekiddfkaedfqiegynphptikme