SCOPe 2.04: Domain d3eqda_: 3eqd A:

Lineage for d3eqda_ (3eqd A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (17 PDB entries)
   Uniprot Q02750 61-381

8. Domain d3eqda_: 3eqd A: [209609]
   automated match to d1s9ia_
   complexed with ags, ca, mg, na

Details for d3eqda_

PDB Entry: 3eqd, 2.1 Å

PDB Description: x-ray structure of the human mitogen-activated protein kinase kinase 1 (mek1) in a binary complex with atp-gs and mg2p

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3eqda_:

Sequence, based on SEQRES records:

>d3eqda_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcq
vegdaaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfslefqdfv
nkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d3eqda_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcp
maifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdae
evdfagwlcstigln

Timeline for d3eqda_:

• d3eqda_ first appeared in SCOPe 2.03
  
• d3eqda_ appears in SCOPe 2.05
  
• d3eqda_ appears in the current release, SCOPe 2.08