SCOPe 2.07: Domain d1zrqa_: 1zrq A:

Lineage for d1zrqa_ (1zrq A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

8. Domain d1zrqa_: 1zrq A: [203361]
   automated match to d1b5tb_
   complexed with fad, nai, so4

Details for d1zrqa_

PDB Entry: 1zrq, 2.2 Å

PDB Description: escherichia coli methylenetetrahydrofolate reductase (reduced) complexed with nadh, ph 6.0

PDB Compounds: (A:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d1zrqa_:

Sequence, based on SEQRES records:

>d1zrqa_ c.1.23.1 (A:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
ffhasqrdalnqslaevqgqinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtyga
nsgerdrthsiikgikdrtgleaaphltcidatpdelrtiardywnngirhivalrgdlp
pgsgkpemyasdlvtllkevadfdisvaaypevhpeaksaqadllnlkrkvdaganrait
qfffdvesylrfrdrcvsagidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgl
dddaetrklvganiamdmvkilsregvkdfhfytlnraemsyaichtlgvrp

Sequence, based on observed residues (ATOM records):

>d1zrqa_ c.1.23.1 (A:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
ffhasqrdalnqslaevqgqinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtyga
drthsiikgikdrtgleaaphltcidatpdelrtiardywnngirhivalrgdlpemyas
dlvtllkevadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylr
frdrcvsagidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvg
aniamdmvkilsregvkdfhfytlnraemsyaichtlgvrp

Timeline for d1zrqa_:

• d1zrqa_ first appeared in SCOPe 2.03
  
• d1zrqa_ appears in SCOPe 2.06
  
• d1zrqa_ appears in the current release, SCOPe 2.08