SCOPe 2.07: Domain d4eo6a1: 4eo6 A:3-562

Lineage for d4eo6a1 (4eo6 A:3-562)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus genotype 1b (isolate bk) [TaxId:11105] [195056] (4 PDB entries)

8. Domain d4eo6a1: 4eo6 A:3-562 [201886]
   Other proteins in same PDB: d4eo6a2, d4eo6b2
   automated match to d4eo6b_
   protein/RNA complex; complexed with 0s2

Details for d4eo6a1

PDB Entry: 4eo6, 1.79 Å

PDB Description: HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4eo6a1:

Sequence, based on SEQRES records:

>d4eo6a1 e.8.1.4 (A:3-562) Viral RNA polymerase {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
sytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvldd
hyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsv
wkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvstl
pqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqc
cdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaa
craaklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlel
itscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwar
milmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgei
nrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaa
sqldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d4eo6a1 e.8.1.4 (A:3-562) Viral RNA polymerase {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
sytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvldd
hyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsv
wkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvm
gssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlap
earqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraak
lqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlelitscs
snvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmt
hffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvas
clrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasqldl
sgwfvagysggdiyh

Timeline for d4eo6a1:

• d4eo6a1 first appeared in SCOPe 2.03, called d4eo6a_
  
• d4eo6a1 appears in SCOPe 2.06
  
• d4eo6a1 appears in the current release, SCOPe 2.08