SCOPe 2.07: Superfamily e.8.1: DNA/RNA polymerases

Lineage for Superfamily e.8.1: DNA/RNA polymerases

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

Families:

1. e.8.1.1: DNA polymerase I [56673] (5 proteins)

2. e.8.1.2: Reverse transcriptase [56686] (3 proteins)

3. e.8.1.3: T7 RNA polymerase [56691] (2 proteins)

4. e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

5. e.8.1.6: dsRNA phage RNA-dependent RNA-polymerase [64480] (1 protein)
   automatically mapped to Pfam PF00680

6. e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain [100888] (5 proteins)
   contains a distinct 'fingers' domain possibly related to the C-terminal subdomain of hypothetical protein Ta1206 (1qw2)

7. e.8.1.8: Splicing factor Prp8 RT domain [345981] (2 proteins)
   Pfam PF10598, Pfam PF10597. Includes linker domain discussed in PubMed 23354046
   Homology to retroviral RT domains discussed in PubMed 21441348

8. e.8.1.0: automated matches [227142] (1 protein)
   not a true family

More info for Superfamily e.8.1: DNA/RNA polymerases

Timeline for Superfamily e.8.1: DNA/RNA polymerases:

• Superfamily e.8.1: DNA/RNA polymerases first appeared (with stable ids) in SCOP 1.55
  
• Superfamily e.8.1: DNA/RNA polymerases appears in SCOPe 2.06
  
• Superfamily e.8.1: DNA/RNA polymerases appears in the current release, SCOPe 2.08