SCOPe 2.04: Domain d4i3za_: 4i3z A:

Lineage for d4i3za_ (4i3z A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (340 PDB entries)
   Uniprot P24941

8. Domain d4i3za_: 4i3z A: [194182]
   Other proteins in same PDB: d4i3zb1, d4i3zb2, d4i3zd1, d4i3zd2
   automated match to d3bhta_
   complexed with adp, cl, gol, mg

Details for d4i3za_

PDB Entry: 4i3z, 2.05 Å

PDB Description: structure of pcdk2/cyclina bound to adp and 2 magnesium ions

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4i3za_:

Sequence; same for both SEQRES and ATOM records:

>d4i3za_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d4i3za_:

• d4i3za_ first appeared in SCOPe 2.02
  
• d4i3za_ appears in SCOPe 2.03
  
• d4i3za_ appears in SCOPe 2.05
  
• d4i3za_ appears in the current release, SCOPe 2.08