SCOPe 2.07: Domain d3riya1: 3riy A:34-302

Lineage for d3riya1 (3riy A:34-302)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein automated matches [191258] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189817] (4 PDB entries)

8. Domain d3riya1: 3riy A:34-302 [184995]
   Other proteins in same PDB: d3riya2, d3riyb2
   automated match to d2b4ya1
   complexed with nad, zn

Details for d3riya1

PDB Entry: 3riy, 1.55 Å

PDB Description: sirt5 is an nad-dependent protein lysine demalonylase and desuccinylase

PDB Compounds: (A:) NAD-dependent deacetylase sirtuin-5

SCOPe Domain Sequences for d3riya1:

Sequence; same for both SEQRES and ATOM records:

>d3riya1 c.31.1.5 (A:34-302) automated matches {Human (Homo sapiens) [TaxId: 9606]}
arpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafah
npsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtkn
lleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcg
gllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvae
fntettpatnrfrfhfqgpcgttlpeala

Timeline for d3riya1:

• d3riya1 first appeared in SCOPe 2.01, called d3riya_
  
• d3riya1 appears in SCOPe 2.06
  
• d3riya1 appears in the current release, SCOPe 2.08