SCOPe 2.08: Domain d3pyya1: 3pyy A:265-519

Lineage for d3pyya1 (3pyy A:265-519)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3pyya1: 3pyy A:265-519 [184086]
   Other proteins in same PDB: d3pyya2, d3pyyb2
   automated match to d1opjb_
   complexed with 2pe, 3yy, gol, so4, sti

Details for d3pyya1

PDB Entry: 3pyy, 1.85 Å

PDB Description: discovery and characterization of a cell-permeable, small-molecule c- abl kinase activator that binds to the myristoyl binding site

PDB Compounds: (A:) V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant

SCOPe Domain Sequences for d3pyya1:

Sequence, based on SEQRES records:

>d3pyya1 d.144.1.7 (A:265-519) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkeikhpnlvqllgvc
treppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekknfihrdla
arnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwaf
gvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrps
faeihqafetmfqes

Sequence, based on observed residues (ATOM records):

>d3pyya1 d.144.1.7 (A:265-519) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hklgggqygevyegvwkkysltvavktlkeveeflkeaavmkeikhpnlvqllgvctrep
pfyiitefmtygnlldylrecnrqevnavvllymatqissameylekknfihrdlaarnc
lvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwafgvll
weiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaei
hqafetmfqes

Timeline for d3pyya1:

• d3pyya1 first appeared in SCOPe 2.01, called d3pyya_
  
• d3pyya1 appears in SCOPe 2.07