SCOPe 2.01: Domain d3poza_: 3poz A:

Lineage for d3poza_ (3poz A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (15 PDB entries)
   Uniprot P00533 702-1018

8. Domain d3poza_: 3poz A: [183915]
   automated match to d1m14a_
   complexed with 03p, so4

Details for d3poza_

PDB Entry: 3poz, 1.5 Å

PDB Description: EGFR Kinase domain complexed with tak-285

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3poza_:

Sequence, based on SEQRES records:

>d3poza_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeil
deayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikw
malesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppict
idvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyra
lmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records):

>d3poza_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
qallrilketefkkikvlgsgafgtvykglwipvkipvaikelankeildeayvmasvdn
phvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyledr
rlvhrdlaarnvlvktpqhvkitdfglakllgaeekkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidadsr
pkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdvvdadeyl

Timeline for d3poza_:

• d3poza_ is new in SCOPe 2.01-stable
  
• d3poza_ appears in SCOPe 2.02
  
• d3poza_ appears in the current release, SCOPe 2.08