SCOPe 2.01: Family d.144.1.7: Protein kinases, catalytic subunit

Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

Proteins:

1. 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [90037] (17 PDB entries)
     Uniprot O15530 75-363

2. Abelsone tyrosine kinase (abl) [56166] (1 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

   • Species Mouse (Mus musculus) [TaxId:10090] [56167] (9 PDB entries)

3. Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [111201] (5 PDB entries)
     Uniprot Q07912 117-389

4. Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [90039] (9 PDB entries)

5. B-Raf kinase [103290] (1 species)
   OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

   • Species Human (Homo sapiens) [TaxId:9606] [103291] (2 PDB entries)

6. Bruton's tyrosine kinase (Btk) [75564] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [75565] (1 PDB entry)

7. c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [56138] (24 PDB entries)

8. c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [103297] (5 PDB entries)
     Uniprot P10721 547-935

9. c-src tyrosine kinase [56155] (2 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

   1. Species Chicken (Gallus gallus) [TaxId:9031] [56157] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [56156] (8 PDB entries)

10. Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [56121] (1 PDB entry)

11. cAMP-dependent PK, catalytic subunit [56116] (4 species)
    AGC group; PKA subfamily; serine/threonine kinase

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)

    2. Species Cow (Bos taurus) [TaxId:9913] [56118] (39 PDB entries)
       Uniprot P00517

    3. Species Mouse (Mus musculus) [TaxId:10090] [56119] (24 PDB entries)

    4. Species Pig (Sus scrofa) [TaxId:9823] [56117] (9 PDB entries)

12. Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56165] (3 PDB entries)

13. Casein kinase-1, CK1 [56139] (2 species)
    OPK group; CKI subfamily; serine/threonine kinase

    1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)

14. Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [64405] (41 PDB entries)

15. Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118140] (1 PDB entry)
      Uniprot P50613 13-311

16. Cell division protein kinase 9, CDK9 [160810] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [160811] (1 PDB entry)
      Uniprot P50750 8-325

17. Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [88856] (204 PDB entries)
       Uniprot P24941

    2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
       CDK2 homologue Pfpk5

18. Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [88858] (5 PDB entries)
      Uniprot Q00535

19. Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [88860] (9 PDB entries)

20. Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [75561] (6 PDB entries)
      Uniprot P53355 2-285

21. Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118138] (6 PDB entries)
      Uniprot Q02750 61-381

22. Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118136] (1 PDB entry)
      Uniprot P36507 60-393

23. EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82796] (15 PDB entries)
      Uniprot P00533 702-1018

24. epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103295] (1 PDB entry)

25. ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase

    • Species Mouse (Mus musculus) [TaxId:10090] [69828] (1 PDB entry)

26. Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56159] (8 PDB entries)

27. Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [75563] (3 PDB entries)
      Uniprot P21802 467-765

28. Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103299] (1 PDB entry)

29. Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

    1. Species Chicken (Gallus gallus) [TaxId:9031] [187336] (2 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [103293] (4 PDB entries)

30. G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase

    • Species Cow (Bos taurus) [TaxId:9913] [90035] (3 PDB entries)

31. gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [56123] (3 PDB entries)

32. Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [69824] (21 PDB entries)
      Uniprot P49841 35-383 ! Uniprot P49841 35-384

33. Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56152] (4 PDB entries)

34. Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103301] (19 PDB entries)

35. Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56163] (15 PDB entries)

36. Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [69826] (15 PDB entries)

37. Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56154] (33 PDB entries)

38. MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82790] (5 PDB entries)

39. MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [56135] (1 PDB entry)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (10 PDB entries)

40. MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [56130] (136 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [56131] (5 PDB entries)

41. MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56133] (1 PDB entry)

42. Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111203] (2 PDB entries)
      Uniprot P45983 9-363

43. Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [82798] (1 PDB entry)

44. Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase

    • Species Mycobacterium tuberculosis [TaxId:1773] [82794] (3 PDB entries)

45. pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56147] (9 PDB entries)

46. Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82792] (16 PDB entries)

47. Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118130] (1 PDB entry)
      Uniprot Q04759 377-696

48. Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [75559] (27 PDB entries)

    2. Species Maize (Zea mays) [TaxId:4577] [56143] (28 PDB entries)

    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)

49. Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111197] (1 PDB entry)
      Uniprot Q9JIH7 211-480

50. Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118134] (29 PDB entries)
      Uniprot P11309 33-305 ! Uniprot P11309 32-308

51. Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111193] (1 PDB entry)
      Uniprot O75582 24-345

52. Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [118128] (3 PDB entries)
      Uniprot Q9JLS3 12-320

53. Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)

    • Species Human (Homo sapiens) [TaxId:9606] [143894] (1 PDB entry)
      Uniprot P51955 3-271

54. Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56149] (5 PDB entries)

55. STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [160813] (3 PDB entries)
      Uniprot Q9H2G2 21-308

56. Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [64407] (1 PDB entry)

57. Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56125] (1 PDB entry)

58. Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    1. Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)

    2. Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)

59. Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

    • Species Human (Homo sapiens) [TaxId:9606] [56145] (8 PDB entries)
      Uniprot P36897 200-500 ! Uniprot P36897 201-503

60. Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111195] (3 PDB entries)
      Uniprot Q08881 357-619

61. Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118132] (8 PDB entries)
      Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

62. Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111199] (1 PDB entry)
      Uniprot P43403 328-606 # structure of the N-terminal SH2 domains (1-132;133-256) is also known: 1m61 (89997)

63. Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56161] (20 PDB entries)

64. automated matches [190091] (8 species)
    not a true protein

    1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (6 PDB entries)

    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)

    3. Species Chicken (Gallus gallus) [TaxId:9031] [187329] (4 PDB entries)

    4. Species Cow (Bos taurus) [TaxId:9913] [187007] (27 PDB entries)

    5. Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)

    6. Species Human (Homo sapiens) [TaxId:9606] [188447] (254 PDB entries)

    7. Species Mouse (Mus musculus) [TaxId:10090] [187169] (25 PDB entries)

    8. Species Norway rat (Rattus norvegicus) [TaxId:10116] [187105] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit:

• Family d.144.1.7: Protein kinases, catalytic subunit first appeared in SCOP 1.65
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in SCOP 1.75
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in SCOPe 2.02
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in the current release, SCOPe 2.08