SCOPe 2.04: Domain d3nu0a_: 3nu0 A:

Lineage for d3nu0a_ (3nu0 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d3nu0a_: 3nu0 A: [182543]
   automated match to d1drfa_
   complexed with 3tu, ndp, so4

Details for d3nu0a_

PDB Entry: 3nu0, 1.35 Å

PDB Description: design, synthesis, biological evaluation and x-ray crystal structure of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

PDB Compounds: (A:) Dihydrofolate reducatase

SCOPe Domain Sequences for d3nu0a_:

Sequence; same for both SEQRES and ATOM records:

>d3nu0a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d3nu0a_:

• d3nu0a_ first appeared in SCOPe 2.01
  
• d3nu0a_ appears in SCOPe 2.03
  
• d3nu0a_ appears in SCOPe 2.05
  
• d3nu0a_ appears in the current release, SCOPe 2.08