SCOPe 2.06: Domain d3mwva_: 3mwv A:

Lineage for d3mwva_ (3mwv A:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (18 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d3mwva_: 3mwv A: [181653]
   automated match to d1nb4a_

Details for d3mwva_

PDB Entry: 3mwv, 2.2 Å

PDB Description: crystal structure of hcv ns5b polymerase

PDB Compounds: (A:) Genome polyprotein

SCOPe Domain Sequences for d3mwva_:

Sequence, based on SEQRES records:

>d3mwva_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3mwva_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
avmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccd
lapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacr
aaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinr
vasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasq
ldlsgwfvagysggdiyhs

Timeline for d3mwva_:

• d3mwva_ first appeared in SCOPe 2.01
  
• d3mwva_ appears in SCOPe 2.05
  
• d3mwva_ appears in SCOPe 2.07
  
• d3mwva_ appears in the current release, SCOPe 2.08