SCOPe 2.07: Domain d3lp2b_: 3lp2 B:

Lineage for d3lp2b_ (3lp2 B:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (204 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d3lp2b_: 3lp2 B: [180483]
   Other proteins in same PDB: d3lp2a2, d3lp2a3
   automated match to d1c1cb_
   protein/DNA complex; protein/RNA complex; complexed with lp9, mn

Details for d3lp2b_

PDB Entry: 3lp2, 2.8 Å

PDB Description: hiv-1 reverse transcriptase with inhibitor

PDB Compounds: (B:) p51 RT

SCOPe Domain Sequences for d3lp2b_:

Sequence, based on SEQRES records:

>d3lp2b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

Sequence, based on observed residues (ATOM records):

>d3lp2b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikt
kwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyv
gsdleigqhrtkieelrqhllrwgltgyelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyarhtndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d3lp2b_:

• d3lp2b_ first appeared in SCOPe 2.01
  
• d3lp2b_ appears in SCOPe 2.06
  
• d3lp2b_ appears in the current release, SCOPe 2.08