SCOPe 2.03: Domain d3igla_: 3igl A:

Lineage for d3igla_ (3igl A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10 superfamilies)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold

4. Superfamily b.2.5: p53-like transcription factors [49417] (7 families)

5. Family b.2.5.2: p53 DNA-binding domain-like [81314] (3 proteins)

6. Protein p53 tumor suppressor, DNA-binding domain [49419] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49420] (32 PDB entries)

8. Domain d3igla_: 3igl A: [178311]
   automated match to d1gzha_
   protein/DNA complex; protein/RNA complex; complexed with edo, zn

Details for d3igla_

PDB Entry: 3igl, 1.8 Å

PDB Description: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)

PDB Compounds: (A:) Cellular tumor antigen p53

SCOPe Domain Sequences for d3igla_:

Sequence, based on SEQRES records:

>d3igla_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

Sequence, based on observed residues (ATOM records):

>d3igla_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvca
cpgrdrrteeenlrkkg

Timeline for d3igla_:

• d3igla_ first appeared in SCOPe 2.01
  
• d3igla_ appears in SCOPe 2.02
  
• d3igla_ appears in SCOPe 2.04
  
• d3igla_ appears in the current release, SCOPe 2.08