PDB entry 3igl

View 3igl on RCSB PDB site
Description: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)
Class: transcription/DNA
Keywords: P53, MUTANT PROTEIN, LOOP-SHEET-HELIX MOTIF, DNA TARGET, ACTIVATOR, ANTI-ONCOGENE APOPTOSIS, CELL CYCLE, COVALENT PROTEIN-RNA LINKAGE, DISEASE MUTATION, DNA-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HOST-VIRUS INTERACTION, LI-FRAUMENI SYNDROME, METAL-BINDING, METHYLATION, NUCLEUS, PHOSPHOPROTEIN, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSCRIPTION/DNA COMPLE, Apoptosis, Isopeptide bond, Tumor suppressor, TRANSCRIPTION-DNA complex
Deposited on 2009-07-28, released 2010-03-31
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-06-08, with a file datestamp of 2011-06-03.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.151
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Cellular tumor antigen p53
  Species: Homo sapiens [TaxId:9606]
  Gene: TP53
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04637 (0-199)
  Domains in SCOPe 2.03: d3igla_
• Chain 'B':
  Compound: DNA (5'-d(*cp*gp*gp*gp*cp*ap*tp*gp*cp*cp*cp*g)-3')
  Species: synthetic, synthetic
  
• Heterogens: ZN, EDO, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3iglA (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
  hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevr
  vcacpgrdrrteeenlrkkg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3iglA (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqhmtevvrrcphhercsglappqhlirvegnlrveylddrntfrhsv
  vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvca
  cpgrdrrteeenlrkkg
  

  
  
• Chain 'B':
  No sequence available.