SCOPe 2.06: Domain d3f5pe1: 3f5p E:981-1285

Lineage for d3f5pe1 (3f5p E:981-1285)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (18 PDB entries)

8. Domain d3f5pe1: 3f5p E:981-1285 [175490]
   Other proteins in same PDB: d3f5pa2, d3f5pb2, d3f5pc2, d3f5pd2, d3f5pe2, d3f5pf2, d3f5pg2, d3f5ph2, d3f5pi2, d3f5pj2, d3f5pk2, d3f5pl2, d3f5pm2, d3f5pr2, d3f5ps2, d3f5pt2
   automated match to d1p4ob_
   complexed with 741

Details for d3f5pe1

PDB Entry: 3f5p, 2.9 Å

PDB Description: complex structure of insulin-like growth factor receptor and 3- cyanoquinoline inhibitor

PDB Compounds: (E:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d3f5pe1:

Sequence, based on SEQRES records:

>d3f5pe1 d.144.1.7 (E:981-1285) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
fsaadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaas
mrerieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemen
npvlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdi
yetdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneq
vlrfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfy
yseen

Sequence, based on observed residues (ATOM records):

>d3f5pe1 d.144.1.7 (E:981-1285) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
fsaadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaas
mrerieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpepvl
appslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetd
yyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrf
vmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyysee
n

Timeline for d3f5pe1:

• d3f5pe1 first appeared in SCOPe 2.01, called d3f5pe_
  
• d3f5pe1 was called d3f5pe_ in SCOPe 2.05
  
• d3f5pe1 appears in SCOPe 2.07
  
• d3f5pe1 appears in the current release, SCOPe 2.08