SCOPe 2.06: Structural Classification of Proteins

PDB entry 3f5p

View 3f5p on RCSB PDB site
Description: Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
Class: transferase
Keywords: IGF-1R, protein-inhibitor complex, tyrosine kinase, ATP-binding, Cleavage on pair of basic residues, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2008-11-04, released 2008-12-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.212
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pa1, d3f5pa2
Chain 'B':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pb1, d3f5pb2
Chain 'C':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pc1, d3f5pc2
Chain 'D':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pd1, d3f5pd2
Chain 'E':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pe1, d3f5pe2
Chain 'F':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pf1, d3f5pf2
Chain 'G':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pg1, d3f5pg2
Chain 'H':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5ph1, d3f5ph2
Chain 'I':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pi1, d3f5pi2
Chain 'J':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pj1, d3f5pj2
Chain 'K':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pk1, d3f5pk2
Chain 'L':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pl1, d3f5pl2
Chain 'M':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pm1, d3f5pm2
Chain 'R':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-End)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pr1, d3f5pr2
Chain 'S':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5ps1, d3f5ps2
Chain 'T':
Compound: insulin-like growth factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: IGF1R
Database cross-references and differences (RAF-indexed):
- Uniprot P08069 (2-307)
  - expression tag (1)
Domains in SCOPe 2.06: d3f5pt1, d3f5pt2
Heterogens: 741, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3f5pA (A:)
gsfsaadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvnea
asmrerieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpem
ennpvlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtr
diyetdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsn
eqvlrfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevs
fyyseenk