SCOPe 2.07: Domain d3dwfb_: 3dwf B:

Lineage for d3dwfb_ (3dwf B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
   Uniprot Q6QLL4 23-296

8. Domain d3dwfb_: 3dwf B: [174302]
   automated match to d1xsea_
   complexed with gol, nap, so4; mutant

Details for d3dwfb_

PDB Entry: 3dwf, 2.2 Å

PDB Description: crystal structure of the guinea pig 11beta-hydroxysteroid dehydrogenase type 1 mutant f278e

PDB Compounds: (B:) 11-beta-hydroxysteroid dehydrogenase 1

SCOPe Domain Sequences for d3dwfb_:

Sequence; same for both SEQRES and ATOM records:

>d3dwfb_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Guinea pig (Cavia porcellus) [TaxId: 10141]}
ekfrpemlqgkkvivtgaskgigreiayhlakmgahvvvtarskealqkvvarclelgaa
sahyiagsmedmtfaeefvaeagnlmggldmlilnhvlynrltffhgeidnvrksmevnf
hsfvvlsvaampmlmqsqgsiavvssvagkitypliapysaskfaldgffstlrseflvn
kvnvsitlcilglidtetaikatsgiylgpaspkeecaleiikgtalrqdemyyvgsrwv
pyllgnpgrkimeelsaaeynwdnvlsneklygrw

Timeline for d3dwfb_:

• d3dwfb_ first appeared in SCOPe 2.01
  
• d3dwfb_ appears in SCOPe 2.06
  
• d3dwfb_ appears in the current release, SCOPe 2.08