SCOPe 2.07: Domain d3dwfa1: 3dwf A:25-293

Lineage for d3dwfa1 (3dwf A:25-293)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
   Uniprot Q6QLL4 23-296

8. Domain d3dwfa1: 3dwf A:25-293 [174301]
   automated match to d1xsea_
   complexed with gol, nap, so4; mutant

Details for d3dwfa1

PDB Entry: 3dwf, 2.2 Å

PDB Description: crystal structure of the guinea pig 11beta-hydroxysteroid dehydrogenase type 1 mutant f278e

PDB Compounds: (A:) 11-beta-hydroxysteroid dehydrogenase 1

SCOPe Domain Sequences for d3dwfa1:

Sequence; same for both SEQRES and ATOM records:

>d3dwfa1 c.2.1.2 (A:25-293) 11-beta-hydroxysteroid dehydrogenase 1 {Guinea pig (Cavia porcellus) [TaxId: 10141]}
ekfrpemlqgkkvivtgaskgigreiayhlakmgahvvvtarskealqkvvarclelgaa
sahyiagsmedmtfaeefvaeagnlmggldmlilnhvlynrltffhgeidnvrksmevnf
hsfvvlsvaampmlmqsqgsiavvssvagkitypliapysaskfaldgffstlrseflvn
kvnvsitlcilglidtetaikatsgiylgpaspkeecaleiikgtalrqdemyyvgsrwv
pyllgnpgrkimeelsaaeynwdnvlsne

Timeline for d3dwfa1:

• d3dwfa1 first appeared in SCOPe 2.01
  
• d3dwfa1 appears in SCOPe 2.06
  
• d3dwfa1 appears in the current release, SCOPe 2.08