SCOPe 2.06: Domain d2fvca_: 2fvc A:

Lineage for d2fvca_ (2fvc A:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (18 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d2fvca_: 2fvc A: [164476]
   automated match to d1nb4a_
   complexed with 888

Details for d2fvca_

PDB Entry: 2fvc, 2 Å

PDB Description: crystal structure of ns5b bk strain (delta 24) in complex with a 3-(1, 1-dioxo-2h-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1h)-quinolinone

PDB Compounds: (A:) Polyprotein

SCOPe Domain Sequences for d2fvca_:

Sequence; same for both SEQRES and ATOM records:

>d2fvca_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagvqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhs

Timeline for d2fvca_:

• d2fvca_ first appeared in SCOPe 2.01
  
• d2fvca_ appears in SCOPe 2.05
  
• d2fvca_ appears in SCOPe 2.07
  
• d2fvca_ appears in the current release, SCOPe 2.08