SCOPe 2.01: Domain d2vrwa_: 2vrw A:

Lineage for d2vrwa_ (2vrw A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (79 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein automated matches [190047] (13 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186768] (67 PDB entries)

8. Domain d2vrwa_: 2vrw A: [153524]
   automated match to d1hh4a_
   complexed with zn

Details for d2vrwa_

PDB Entry: 2vrw, 1.85 Å

PDB Description: critical structural role for the ph and c1 domains of the vav1 exchange factor

PDB Compounds: (A:) ras-related c3 botulinum toxin substrate 1

SCOPe Domain Sequences for d2vrwa_:

Sequence; same for both SEQRES and ATOM records:

>d2vrwa_ c.37.1.8 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl

Timeline for d2vrwa_:

• d2vrwa_ first appeared in SCOP 1.75, called d2vrwa1
  
• d2vrwa_ appears in SCOPe 2.02
  
• d2vrwa_ appears in the current release, SCOPe 2.08