Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 987024Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 987025Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families) (S)
    division into families based on beta-sheet topologies
  5. 987698Family c.37.1.8: G proteins [52592] (79 proteins)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

  1. 987699ADP-ribosylation factor [52614] (15 species)
    1. 987700Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 987702Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 987705Species Human (Homo sapiens) [TaxId:9606] [142220] (1 PDB entry)
      Uniprot P84085 6-179
    4. 987707Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (9 PDB entries)
      Uniprot P32889
    5. 987725Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 987728Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 987735Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (2 PDB entries)
    8. 987744Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 987746Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 987748Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 987750Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 987752Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)
    13. 987756Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (2 PDB entries)
    14. 987759Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    15. 987763Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
  2. 987766CDC42 [52619] (2 species)
    1. 987767Species Human (Homo sapiens) [TaxId:9606] [52620] (24 PDB entries)
    2. 987804Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry)
  3. 987807Centaurin gamma 1, G domain [142249] (1 species)
  4. 987810cH-p21 Ras protein [52593] (1 species)
  5. 987909Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 987914di-Ras1 [142277] (1 species)
  7. 987920di-Ras2 [142267] (1 species)
  8. 987923Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 987924Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 987926Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 987929Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)
  10. 987954Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 987955Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 987962Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 987967Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 987968Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 987979Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 987982Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 987996Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 987997Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 988003Species Escherichia coli [TaxId:562] [52627] (9 PDB entries)
      Uniprot P02990
    3. 988018Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 988027Species Thermus thermophilus [TaxId:274] [52629] (7 PDB entries)
  14. 988041Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 988046GTP-binding protein engB [142257] (1 species)
  16. 988049GTP-binding protein GEM [142289] (1 species)
  17. 988054GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. 988057GTP-binding protein RheB [142275] (1 species)
  19. 988060GTPase Era, N-terminal domain [52637] (2 species)
    1. 988061Species Escherichia coli [TaxId:562] [52638] (3 PDB entries)
    2. 988066Species Thermus thermophilus [TaxId:274] [117533] (1 PDB entry)
      Uniprot Q5SM23
  20. 988068GTPase Ytp1 [110544] (1 species)
  21. 988072Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 988073Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 988075Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 988081Species Sulfolobus solfataricus [TaxId:2287] [142227] (5 PDB entries)
      Uniprot Q980A5 2-206
  22. 988088Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 988093Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 988097Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 988107Obg GTP-binding protein middle domain [82408] (2 species)
    1. 988108Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 988111Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 988113Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 988117Probable GTPase EngB [89667] (2 species)
    1. 988118Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 988124Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 988127Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 988128Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 988130Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  29. 988134Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 988137Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 988140r-Ras [142273] (1 species)
  32. 988143r-Ras2 [142281] (1 species)
  33. 988146Rab-22a [142253] (1 species)
  34. 988150Rab-33b [142279] (1 species)
  35. 988154Rab-related protein Sec4 [52607] (1 species)
  36. 988164Rab-related protein ypt7p [75199] (1 species)
  37. 988168Rab11a [102362] (2 species)
    1. 988169Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (1 PDB entry)
    2. 988174Species Human (Homo sapiens) [TaxId:9606] [102363] (5 PDB entries)
  38. 988182Rab11b [142237] (1 species)
  39. 988186Rab14 [142271] (1 species)
  40. 988189Rab18 [142233] (1 species)
  41. 988192Rab1a [142241] (1 species)
  42. 988195Rab21 [142285] (1 species)
  43. 988200Rab23 [142231] (1 species)
  44. 988203Rab26 [142259] (1 species)
  45. 988206Rab27b [142263] (1 species)
  46. 988210Rab2a [142265] (1 species)
  47. 988213Rab2b [142287] (1 species)
  48. 988216Rab30 [142239] (1 species)
  49. 988219Rab31 [142235] (1 species)
  50. 988222Rab3a [52601] (1 species)
  51. 988226Rab4a [142247] (1 species)
  52. 988232Rab5a [82399] (1 species)
  53. 988254Rab5c [52603] (1 species)
  54. 988260Rab6 [52605] (2 species)
    1. 988261Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 988263Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 988265Rab7 [110540] (2 species)
    1. 988266Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 988272Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  56. 988283Rab8a [142293] (1 species)
  57. 988287Rab9a [110537] (3 species)
    1. 988288Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 988291Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 988294Species Mouse (Mus musculus) [TaxId:10090] [142229] (1 PDB entry)
      Uniprot Q9R0M6 4-175
  58. 988296Rac [52595] (1 species)
  59. 988325Rac3 [142255] (1 species)
  60. 988328Rad [142295] (1 species)
  61. 988331Ran [52609] (2 species)
    1. 988332Species Dog (Canis familiaris) [TaxId:9615] [52610] (7 PDB entries)
      Uniprot P62825
    2. 988348Species Human (Homo sapiens) [TaxId:9606] [52611] (8 PDB entries)
  62. 988367Rap1A [52597] (1 species)
  63. 988371Rap2a [52599] (1 species)
  64. 988377Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 988380Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 988383Ras-related protein RalA [89662] (2 species)
    1. 988384Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 988391Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 988400RhoA [52612] (1 species)
  68. 988437RhoB [142243] (1 species)
  69. 988440RhoC [142245] (1 species)
  70. 988444RhoE (RND3) [75201] (1 species)
  71. 988449RhoQ [142261] (1 species)
  72. 988453SAR1 [69483] (3 species)
    1. 988454Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 988458Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 988461Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  73. 988464Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 988465Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 988467Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  74. 988470Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 988473Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 988474Species Cow (Bos taurus) [TaxId:9913] [52624] (15 PDB entries)
      Uniprot P04896 39-388
    2. 988495Species Human (Homo sapiens) [TaxId:9606] [159560] (3 PDB entries)
    3. 988500Species Mouse (Mus musculus) [TaxId:10090] [142225] (4 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 988507Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (26 PDB entries)
      Uniprot P10824
  76. 988545TrmE GTPase domain [117535] (1 species)
  77. 988549YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 988550Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 988552Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 988555Ypt51 [52621] (1 species)
  79. 988558automated matches [190047] (13 species)
    not a true protein
    1. 988559Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (2 PDB entries)
    2. 988564Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    3. 988569Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    4. 988571Species Escherichia coli [TaxId:469008] [187117] (3 PDB entries)
    5. 988582Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    6. 988585Species Human (Homo sapiens) [TaxId:9606] [186768] (67 PDB entries)
    7. 988714Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    8. 988716Species Mouse (Mus musculus) [TaxId:10090] [186896] (7 PDB entries)
    9. 988729Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    10. 988738Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    11. 988744Species Pyrococcus horikoshii [TaxId:70601] [187582] (1 PDB entry)
    12. 988747Species Saccharomyces cerevisiae [TaxId:559292] [189771] (2 PDB entries)
    13. 988751Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (6 PDB entries)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: