SCOPe 2.04: Domain d2uzld1: 2uzl D:176-309

Lineage for d2uzld1 (2uzl D:176-309)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (74 PDB entries)
   Uniprot P20248 175-432

8. Domain d2uzld1: 2uzl D:176-309 [152351]
   Other proteins in same PDB: d2uzla_, d2uzlc_
   automated match to d1h1pb1
   complexed with c94

Details for d2uzld1

PDB Entry: 2uzl, 2.4 Å

PDB Description: crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

PDB Compounds: (D:) cyclin a2

SCOPe Domain Sequences for d2uzld1:

Sequence; same for both SEQRES and ATOM records:

>d2uzld1 a.74.1.1 (D:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaap

Timeline for d2uzld1:

• d2uzld1 first appeared in SCOP 1.75
  
• d2uzld1 appears in SCOPe 2.03
  
• d2uzld1 appears in SCOPe 2.05
  
• d2uzld1 appears in the current release, SCOPe 2.08