SCOPe 2.06: Domain d2qyna_: 2qyn A:

Lineage for d2qyna_ (2qyn A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89152] (39 PDB entries)
   Uniprot Q08499 388-713

8. Domain d2qyna_: 2qyn A: [151475]
   automated match to d1mkda_
   complexed with mg, npv, zn

Details for d2qyna_

PDB Entry: 2qyn, 1.57 Å

PDB Description: Crystal structure of PDE4D2 in complex with inhibitor NPV

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4D

SCOPe Domain Sequences for d2qyna_:

Sequence; same for both SEQRES and ATOM records:

>d2qyna_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
teqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlity
lmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhp
gvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvi
divlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkp
lqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwa
dlvhpdaqdildtlednrewyqstip

Timeline for d2qyna_:

• d2qyna_ first appeared in SCOP 1.75, called d2qyna1
  
• d2qyna_ appears in SCOPe 2.05
  
• d2qyna_ appears in SCOPe 2.07
  
• d2qyna_ appears in the current release, SCOPe 2.08