SCOPe 2.07: Domain d2qmga_: 2qmg A:

Lineage for d2qmga_ (2qmg A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2qmga_: 2qmg A: [150882]
   automated match to d1fkna_
   complexed with sc6, tar

Details for d2qmga_

PDB Entry: 2qmg, 1.89 Å

PDB Description: structure of bace bound to sch745966

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2qmga_:

Sequence; same for both SEQRES and ATOM records:

>d2qmga_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyni

Timeline for d2qmga_:

• d2qmga_ first appeared in SCOP 1.75, called d2qmga1
  
• d2qmga_ appears in SCOPe 2.06
  
• d2qmga_ appears in the current release, SCOPe 2.08