SCOPe 2.04: Domain d2pnrb2: 2pnr B:174-390

Lineage for d2pnrb2 (2pnr B:174-390)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (5 PDB entries)
   Uniprot Q15120 177-301

8. Domain d2pnrb2: 2pnr B:174-390 [149699]
   Other proteins in same PDB: d2pnra1, d2pnrb1, d2pnrc_, d2pnre1, d2pnrf1, d2pnrg_
   automated match to d2bu8a2
   complexed with red

Details for d2pnrb2

PDB Entry: 2pnr, 2.5 Å

PDB Description: Crystal Structure of the asymmetric Pdk3-l2 Complex

PDB Compounds: (B:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3

SCOPe Domain Sequences for d2pnrb2:

Sequence, based on SEQRES records:

>d2pnrb2 d.122.1.4 (B:174-390) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvp
lrkidrlfnymystaprpsleptraaplagfgyglpisrlyaryfqgdlklysmegvgtd
aviylkalssesferlpvfnksawrhykttpeaddws

Sequence, based on observed residues (ATOM records):

>d2pnrb2 d.122.1.4 (B:174-390) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedypavktlvtlgkedlsikisdlgggvplrki
drlfnymglpisrlyaryfqgdlklysmegvgtdaviylkalssesferlpvfnksawrh
yktaddws

Timeline for d2pnrb2:

• d2pnrb2 first appeared in SCOP 1.75
  
• d2pnrb2 appears in SCOPe 2.03
  
• d2pnrb2 appears in SCOPe 2.05
  
• d2pnrb2 appears in the current release, SCOPe 2.08