SCOPe 2.08: Domain d2izva1: 2izv A:386-429

Lineage for d2izva1 (2izv A:386-429)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.271: SOCS box-like [158234] (1 superfamily)
   helix-loop-helix motif with orthogonally packed helices

4. Superfamily a.271.1: SOCS box-like [158235] (2 families)

5. Family a.271.1.1: SOCS box-like [158236] (2 proteins)
   Pfam PF07525

6. Protein Suppressor of cytokine signaling 4, SOCS-4 [158237] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158238] (1 PDB entry)
   Uniprot Q8WXH5 386-429

8. Domain d2izva1: 2izv A:386-429 [145555]
   Other proteins in same PDB: d2izva2, d2izva3, d2izvb_, d2izvc_
   complexed with cl, edo, na

Details for d2izva1

PDB Entry: 2izv, 2.55 Å

PDB Description: crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution

PDB Compounds: (A:) suppressor of cytokine signaling 4

SCOPe Domain Sequences for d2izva1:

Sequence; same for both SEQRES and ATOM records:

>d2izva1 a.271.1.1 (A:386-429) Suppressor of cytokine signaling 4, SOCS-4 {Human (Homo sapiens) [TaxId: 9606]}
pfslqhicrtvicncttydgidalpipssmklylkeyhykskvr

Timeline for d2izva1:

• d2izva1 first appeared in SCOP 1.75
  
• d2izva1 appears in SCOPe 2.07