SCOPe 2.08: Domain d2v0ma1: 2v0m A:30-498

Lineage for d2v0ma1 (2v0m A:30-498)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.1: Cytochrome P450 [48265] (23 proteins)

6. Protein Mammalian cytochrome P450 3a4 [109958] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [109959] (7 PDB entries)
   Uniprot P08684

8. Domain d2v0ma1: 2v0m A:30-498 [140050]
   complexed with hem, kln

Details for d2v0ma1

PDB Entry: 2v0m, 2.8 Å

PDB Description: crystal structure of human p450 3a4 in complex with ketoconazole

PDB Compounds: (A:) cytochrome p450 3a4

SCOPe Domain Sequences for d2v0ma1:

Sequence, based on SEQRES records:

>d2v0ma1 a.104.1.1 (A:30-498) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtqkhrv
dflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyelathpdvqq
klqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfip
kgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfal
mnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdg

Sequence, based on observed residues (ATOM records):

>d2v0ma1 a.104.1.1 (A:30-498) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledvdflql
midsqalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnka
pptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhr
dpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnf
sfkpcketqiplklslggllqpekpvvlkvesrdg

Timeline for d2v0ma1:

• d2v0ma1 first appeared in SCOP 1.73
  
• d2v0ma1 appears in SCOPe 2.07