SCOP 1.75: Domain d2h40a1: 2h40 A:535-860

Lineage for d2h40a1 (2h40 A:535-860)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (5 families)

5. Family a.211.1.2: PDEase [48548] (6 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (15 PDB entries)
   Uniprot O76074 534-860

8. Domain d2h40a1: 2h40 A:535-860 [136063]
   automatically matched to d1t9ra_
   complexed with mg, zn

Details for d2h40a1

PDB Entry: 2h40, 1.85 Å

PDB Description: Crystal structure of the catalytic domain of unliganded PDE5

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOP Domain Sequences for d2h40a1:

Sequence, based on SEQRES records:

>d2h40a1 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d2h40a1 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrekknkipsmqvgfidaiclqlyealthvsedcfplldgcrkn
rqkwqalaeqq

Timeline for d2h40a1:

• d2h40a1 first appeared in SCOP 1.73
  
• d2h40a1 is called d2h40a_ in SCOPe 2.01
  
• d2h40a1 appears in the current release, SCOPe 2.08, called d2h40a_