SCOP 1.75: Domain d2fqia1: 2fqi A:34-396

Lineage for d2fqia1 (2fqi A:34-396)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (11 PDB entries)

8. Domain d2fqia1: 2fqi A:34-396 [133955]
   automatically matched to d1d3ga_
   complexed with act, fmn, ilh, oro, so4

Details for d2fqia1

PDB Entry: 2fqi, 1.95 Å

PDB Description: dual binding modes of a novel series of DHODH inhibitors

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOP Domain Sequences for d2fqia1:

Sequence, based on SEQRES records:

>d2fqia1 c.1.4.1 (A:34-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Sequence, based on observed residues (ATOM records):

>d2fqia1 c.1.4.1 (A:34-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprafqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvs
spntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvke
lgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvg
gvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadh
rr

Timeline for d2fqia1:

• d2fqia1 first appeared in SCOP 1.73
  
• d2fqia1 appears in SCOPe 2.01
  
• d2fqia1 appears in the current release, SCOPe 2.08, called d2fqia_