SCOPe 2.08: Domain d2fqia_: 2fqi A:

Lineage for d2fqia_ (2fqi A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d2fqia_: 2fqi A: [133955]
   automated match to d1d3ga_
   complexed with act, fmn, ilh, oro, so4
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d2fqia_

PDB Entry: 2fqi, 1.95 Å

PDB Description: dual binding modes of a novel series of DHODH inhibitors

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOPe Domain Sequences for d2fqia_:

Sequence, based on SEQRES records:

>d2fqia_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Sequence, based on observed residues (ATOM records):

>d2fqia_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
derfyaehlmptlqglldpesahrlavrftslgllprafqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvs
spntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvke
lgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvg
gvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadh
rr

Timeline for d2fqia_:

• d2fqia_ first appeared in SCOP 1.73, called d2fqia1
  
• d2fqia_ appears in SCOPe 2.07