SCOPe 2.01: Domain d2fm5b1: 2fm5 B:86-412

Lineage for d2fm5b1 (2fm5 B:86-412)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89152] (25 PDB entries)
   Uniprot Q08499 388-713

8. Domain d2fm5b1: 2fm5 B:86-412 [133762]
   automatically matched to d1oyna_
   complexed with m99, mg, zn

Details for d2fm5b1

PDB Entry: 2fm5, 2.03 Å

PDB Description: Crystal structure of PDE4D2 in complex with inhibitor L-869299

PDB Compounds: (B:) cAMP-specific 3',5'-cyclic phosphodiesterase 4D

SCOPe Domain Sequences for d2fm5b1:

Sequence; same for both SEQRES and ATOM records:

>d2fm5b1 a.211.1.2 (B:86-412) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
teqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlity
lmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhp
gvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvi
divlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkp
lqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwa
dlvhpdaqdildtlednrewyqstipq

Timeline for d2fm5b1:

• d2fm5b1 first appeared in SCOP 1.73
  
• d2fm5b1 appears in SCOP 1.75
  
• d2fm5b1 appears in SCOPe 2.02
  
• d2fm5b1 appears in the current release, SCOPe 2.08, called d2fm5b_