SCOPe 2.06: Domain d2ewma1: 2ewm A:3-249

Lineage for d2ewma1 (2ewm A:3-249)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein (s)-1-phenylethanol dehydrogenase [141902] (1 species)

7. Species Azoarcus sp. ebn1 [TaxId:76114] [141903] (2 PDB entries)
   Uniprot Q5P5I4 3-249

8. Domain d2ewma1: 2ewm A:3-249 [132468]
   automatically matched to 2EW8 A:3-249
   complexed with nad, so4

Details for d2ewma1

PDB Entry: 2ewm, 2.4 Å

PDB Description: crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1

PDB Compounds: (A:) (S)-1-Phenylethanol dehydrogenase

SCOPe Domain Sequences for d2ewma1:

Sequence, based on SEQRES records:

>d2ewma1 c.2.1.2 (A:3-249) (s)-1-phenylethanol dehydrogenase {Azoarcus sp. ebn1 [TaxId: 76114]}
qrlkdklavitggangigraiaerfavegadiaiadlvpapeaeaairnlgrrvltvkcd
vsqpgdveafgkqvistfgrcdilvnnagiyplipfdeltfeqwkktfeinvdsgflmak
afvpgmkrngwgriinltsttywlkieaythyistkaanigftralasdlgkdgitvnai
apslvrtatteasalsamfdvlpnmlqaiprlqvpldltgaaaflasddasfitgqtlav
dggmvrh

Sequence, based on observed residues (ATOM records):

>d2ewma1 c.2.1.2 (A:3-249) (s)-1-phenylethanol dehydrogenase {Azoarcus sp. ebn1 [TaxId: 76114]}
qrlkdklavitggangigraiaerfavegadiaiadlvpapeaeaairnlgrrvltvkcd
vsqpgdveafgkqvistfgrcdilvnnagiyplipfdeltfeqwkktfeinvdsgflmak
afvpgmkrngwgriinltsttywlkieaythyistkaanigftralasdlgkdgitvnai
apslvrtattlqaiprlqvpldltgaaaflasddasfitgqtlavdggmvrh

Timeline for d2ewma1:

• d2ewma1 first appeared in SCOP 1.73
  
• d2ewma1 appears in SCOPe 2.05
  
• d2ewma1 appears in SCOPe 2.07
  
• d2ewma1 appears in the current release, SCOPe 2.08