SCOPe 2.08: Domain d1zxca_: 1zxc A:

Lineage for d1zxca_ (1zxc A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (2 proteins)
   automatically mapped to Pfam PF13574
   automatically mapped to Pfam PF13583

6. Protein TNF-alpha converting enzyme, TACE, catalytic domain [55526] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55527] (20 PDB entries)

8. Domain d1zxca_: 1zxc A: [125769]
   automated match to d1bkce_
   complexed with ih6, zn

Details for d1zxca_

PDB Entry: 1zxc, 2.28 Å

PDB Description: crystal structure of catalytic domain of tnf-alpha converting enzyme (tace) with inhibitor

PDB Compounds: (A:) adam 17

SCOPe Domain Sequences for d1zxca_:

Sequence; same for both SEQRES and ATOM records:

>d1zxca_ d.92.1.10 (A:) TNF-alpha converting enzyme, TACE, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgyg
iqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclah
lftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktilt
keadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskq
siyktieskaqecfqersn

Timeline for d1zxca_:

• d1zxca_ first appeared in SCOP 1.73, called d1zxca1
  
• d1zxca_ appears in SCOPe 2.07