SCOPe 2.08: Domain d1xn3d_: 1xn3 D:

Lineage for d1xn3d_ (1xn3 D:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d1xn3d_: 1xn3 D: [122185]
   automated match to d1fkna_

Details for d1xn3d_

PDB Entry: 1xn3, 2 Å

PDB Description: Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues.

PDB Compounds: (D:) Beta-secretase 1

SCOPe Domain Sequences for d1xn3d_:

Sequence; same for both SEQRES and ATOM records:

>d1xn3d_ b.50.1.2 (D:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Timeline for d1xn3d_:

• d1xn3d_ first appeared in SCOP 1.73, called d1xn3d1
  
• d1xn3d_ appears in SCOPe 2.07