Lineage for Family b.50.1.2: Pepsin-like

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Protein Domains:

  1. 2060178Acid protease [50649] (9 species)
    1. 2060179Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (12 PDB entries)
      synonym: saccharopepsin
    2. 2060193Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (8 PDB entries)
      Uniprot P06026 69-393
    3. 2060202Species Fungus (Aspergillus oryzae) [TaxId:5062] [89352] (2 PDB entries)
    4. 2060205Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)
    5. 2060208Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)
    6. 2060223Species Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId:5319] [110246] (1 PDB entry)
      Uniprot P17576 1-329
    7. 2060225Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)
    8. 2060228Species Yeast (Candida albicans) [TaxId:5476] [50653] (4 PDB entries)
    9. 2060233Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)
  2. 2060235beta-secretase (memapsin) [50671] (1 species)
  3. 2060641Cathepsin D [50665] (1 species)
  4. 2060651Chymosin (synonym: renin) [50667] (3 species)
    1. 2060652Species Cow (Bos taurus) [TaxId:9913] [50668] (6 PDB entries)
    2. 2060659Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)
    3. 2060793Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)
  5. 2060798Endothiapepsin [50647] (1 species)
  6. 2060851Pepsin [50663] (1 species)
  7. 2060854Pepsin(ogen) [50658] (4 species)
    1. 2060855Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)
    2. 2060857Species Human (Homo sapiens), isoform 3A [TaxId:9606] [50660] (5 PDB entries)
    3. 2060863Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)
    4. 2060867Species Pig (Sus scrofa) [TaxId:9823] [50659] (8 PDB entries)
  8. 2060877Plant acid proteinase, phytepsin [50655] (2 species)
    1. 2060878Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)
    2. 2060882Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)
  9. 2060885Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)
    1. 2060886Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (22 PDB entries)
    2. 2060930Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (2 PDB entries)
    3. 2060935Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)
  10. 2060940Xylanase inhibitor TAXI-I [110247] (1 species)
    pepsin-like protein that probably lost the protease activity
  11. 2060948automated matches [190156] (4 species)
    not a true protein
    1. 2060949Species Camel (Camelus dromedarius) [TaxId:9838] [197076] (1 PDB entry)
    2. 2060951Species Cryphonectria parasitica [TaxId:5116] [187236] (22 PDB entries)
    3. 2060973Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)
    4. 2061024Species Yeast (Candida albicans) [TaxId:5476] [188488] (4 PDB entries)

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like: