Lineage for Family b.50.1.2: Pepsin-like

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2799129Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2799130Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2800798Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Proteins:

  1. 2800799Acid protease [50649] (9 species)
    1. 2800800Species Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId:4932] [50654] (12 PDB entries)
      synonym: saccharopepsin
    2. 2800814Species Bread mold (Rhizopus chinensis) [TaxId:4843] [50651] (8 PDB entries)
      Uniprot P06026 69-393
    3. 2800823Species Fungus (Aspergillus oryzae) [TaxId:5062] [89352] (2 PDB entries)
    4. 2800826Species Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId:5063] [63794] (1 PDB entry)
    5. 2800829Species Fungus (Penicillium janthinellum), penicillopepsin [TaxId:5079] [50650] (14 PDB entries)
    6. 2800844Species Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId:5319] [110246] (1 PDB entry)
      Uniprot P17576 1-329
    7. 2800846Species Rhizomucor miehei [TaxId:4839] [50652] (2 PDB entries)
    8. 2800849Species Yeast (Candida albicans) [TaxId:5476] [50653] (4 PDB entries)
    9. 2800854Species Yeast (Candida tropicalis) [TaxId:5482] [63795] (1 PDB entry)
  2. 2800856beta-secretase (memapsin) [50671] (1 species)
  3. 2801379Cathepsin D [50665] (1 species)
  4. 2801389Chymosin (synonym: renin) [50667] (3 species)
    1. 2801390Species Cow (Bos taurus) [TaxId:9913] [50668] (6 PDB entries)
    2. 2801397Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)
    3. 2801547Species Mouse (Mus musculus) [TaxId:10090] [50670] (1 PDB entry)
  5. 2801552Endothiapepsin [50647] (1 species)
  6. 2802092Pepsin [50663] (1 species)
  7. 2802095Pepsin(ogen) [50658] (4 species)
    1. 2802096Species Atlantic cod (Gadus morhua) [TaxId:8049] [50662] (1 PDB entry)
    2. 2802098Species Human (Homo sapiens), isoform 3A [TaxId:9606] [50660] (5 PDB entries)
    3. 2802104Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)
    4. 2802108Species Pig (Sus scrofa) [TaxId:9823] [50659] (12 PDB entries)
  8. 2802122Plant acid proteinase, phytepsin [50655] (2 species)
    1. 2802123Species Barley (Hordeum vulgare) [TaxId:4513] [50657] (1 PDB entry)
    2. 2802127Species Cynara cardunculus [TaxId:4265] [50656] (1 PDB entry)
  9. 2802130Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)
    1. 2802131Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (22 PDB entries)
    2. 2802175Species Plasmodium falciparum, plasmepsin IV [TaxId:5833] [74986] (2 PDB entries)
    3. 2802180Species Plasmodium vivax [TaxId:5855] [50675] (2 PDB entries)
  10. 2802185Xylanase inhibitor TAXI-I [110247] (1 species)
    pepsin-like protein that probably lost the protease activity
  11. 2802193automated matches [190156] (5 species)
    not a true protein
    1. 2802194Species Camel (Camelus dromedarius) [TaxId:9838] [197076] (1 PDB entry)
    2. 2802196Species Cryphonectria parasitica [TaxId:5116] [187236] (191 PDB entries)
    3. 2802388Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)
    4. 2802439Species Plasmodium falciparum [TaxId:36329] [354698] (5 PDB entries)
    5. 2802445Species Yeast (Candida albicans) [TaxId:5476] [188488] (4 PDB entries)

More info for Family b.50.1.2: Pepsin-like

Timeline for Family b.50.1.2: Pepsin-like: