SCOPe 2.01: Domain d1unld_: 1unl D:

Lineage for d1unld_ (1unl D:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (3 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (8 proteins)

6. Protein CDK5 activator 1 (NCK5a, p25) [74739] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [74740] (5 PDB entries)
   Uniprot Q15078 145-294

8. Domain d1unld_: 1unl D: [113326]
   Other proteins in same PDB: d1unla_, d1unlb_
   complexed with rrc

Details for d1unld_

PDB Entry: 1unl, 2.2 Å

PDB Description: structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin.

PDB Compounds: (D:) Cyclin-dependent kinase 5 activator 1

SCOPe Domain Sequences for d1unld_:

Sequence; same for both SEQRES and ATOM records:

>d1unld_ a.74.1.1 (D:) CDK5 activator 1 (NCK5a, p25) {Human (Homo sapiens) [TaxId: 9606]}
qastsellrclgeflcrrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvfl
ymlcrdvissevgsdhelqavlltclylsysymgneisyplkpflvesckeafwdrclsv
inlmsskmlqinadphyftqvfsdlknesg

Timeline for d1unld_:

• d1unld_ first appeared in SCOP 1.71
  
• d1unld_ appears in SCOP 1.75
  
• d1unld_ appears in SCOPe 2.02
  
• d1unld_ appears in the current release, SCOPe 2.08