SCOPe 2.01: Domain d1rdtd_: 1rdt D:

Lineage for d1rdtd_ (1rdt D:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (59 PDB entries)
   Uniprot P37231 232-505

8. Domain d1rdtd_: 1rdt D: [111788]
   Other proteins in same PDB: d1rdta_
   complexed with co-activator peptide
   complexed with 570, l79

Details for d1rdtd_

PDB Entry: 1rdt, 2.4 Å

PDB Description: Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

PDB Compounds: (D:) Peroxisome proliferator activated receptor gamma

SCOPe Domain Sequences for d1rdtd_:

Sequence, based on SEQRES records:

>d1rdtd_ a.123.1.1 (D:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
aesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfk
hitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvhei
iytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdla
ifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqi
vtehvqllqvikktetdmslhpllqeiykdly

Sequence, based on observed residues (ATOM records):

>d1rdtd_ a.123.1.1 (D:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
aesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmevairifqg
cqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvliseg
qgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvk
piediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikktetdms
lhpllqeiykdly

Timeline for d1rdtd_:

• d1rdtd_ first appeared in SCOP 1.71
  
• d1rdtd_ appears in SCOP 1.75
  
• d1rdtd_ appears in SCOPe 2.02
  
• d1rdtd_ appears in the current release, SCOPe 2.08, called d1rdtd1