SCOPe 2.08: Family a.216.1.1: I/LWEQ domain

Lineage for Family a.216.1.1: I/LWEQ domain

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.216: I/LWEQ domain [109884] (1 superfamily)
   5 helices; bundle, closed, left-handed twist

4. Superfamily a.216.1: I/LWEQ domain [109885] (1 family)

5. Family a.216.1.1: I/LWEQ domain [109886] (2 proteins)
   Pfam PF01608
   actin-binding motif that adopts different folds; possibly refolds upon binding

Proteins:

1. Huntingtin interacting protein 12 [109887] (1 species)
   Hip1r thatch domain core

   • Species Human (Homo sapiens) [TaxId:9606] [109888] (1 PDB entry)
     Uniprot O75146 773-965

2. Talin 1 [109889] (1 species)
   4-helical bundle of the Bromodomain-like fold (47363); similar to helices 2-5 of the Huntingtin interacting protein 12

   • Species Mouse (Mus musculus) [TaxId:10090] [109890] (2 PDB entries)
     Uniprot P26039 486-782

More info for Family a.216.1.1: I/LWEQ domain

Timeline for Family a.216.1.1: I/LWEQ domain:

• Family a.216.1.1: I/LWEQ domain first appeared in SCOP 1.69, called Family a.216.1.1: I/LWEQ domain (Pfam 01608)
  
• Family a.216.1.1: I/LWEQ domain appears in SCOPe 2.07