SCOPe 2.01: Domain d1um2b1: 1um2 B:284-463,B:699-737

Lineage for d1um2b1 (1um2 B:284-463,B:699-737)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.86: Hedgehog/intein (Hint) domain [51293] (1 superfamily)
   complex fold made of five beta-hairpin units and a b-ribbon arc

4. Superfamily b.86.1: Hedgehog/intein (Hint) domain [51294] (2 families)
   duplication: contains two intertwined structural repeats

5. Family b.86.1.2: Intein (protein splicing domain) [51298] (4 proteins)

6. Protein VMA1-derived endonuclease (VDE) PI-Scei intein [51299] (1 species)
   also contains a homing endonuclease and DNA-binding domains

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51300] (8 PDB entries)
   Uniprot P17255 284-737

8. Domain d1um2b1: 1um2 B:284-463,B:699-737 [107949]
   Other proteins in same PDB: d1um2a2, d1um2a3, d1um2b2, d1um2b3
   complexed with the ligated extein segment (Uniprot P17255 281-283,738-741), chains C and D

Details for d1um2b1

PDB Entry: 1um2, 2.9 Å

PDB Description: crystal structure of the vma1-derived endonuclease with the ligated extein segment

PDB Compounds: (B:) endonuclease pi-scei

SCOPe Domain Sequences for d1um2b1:

Sequence, based on SEQRES records:

>d1um2b1 b.86.1.2 (B:284-463,B:699-737) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqksqhrahk
sdssrevpellkftcnatnelvvrtprsvrrlsrtikgveyfevitfemgqkkapdgriv
elvkevsksypisegperanelvesyrkasnkayfewtieardlsllgshvrkatyqtya
Xcrgfyfelqelkeddyygitlsddsdhqfllanqvvvhn

Sequence, based on observed residues (ATOM records):

>d1um2b1 b.86.1.2 (B:284-463,B:699-737) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqkellkftc
natnelvvrtprsvrrlsrtikgveyfevitfemgqkkapdgrivelvkevsksypiseg
peranelvesyrkasnkayfewtieardlsllgshvrkatyqtyaXcrgfyfelqelked
dyygitlsddsdhqfllanqvvvhn

Timeline for d1um2b1:

• d1um2b1 first appeared in SCOP 1.69
  
• d1um2b1 appears in SCOP 1.75
  
• d1um2b1 appears in SCOPe 2.02
  
• d1um2b1 appears in the current release, SCOPe 2.08