SCOPe 2.08: Domain d1s5il1: 1s5i L:1-107

Lineage for d1s5il1 (1s5i L:1-107)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (132 PDB entries)
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity ! Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR ! Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1 ! Uniprot P01642 21-115 # ! KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10

8. Domain d1s5il1: 1s5i L:1-107 [105274]
   Other proteins in same PDB: d1s5ih1, d1s5ih2, d1s5il2
   MQ P06310 P01837

Details for d1s5il1

PDB Entry: 1s5i, 2.7 Å

PDB Description: fab (lnkb-2) of monoclonal antibody to human interleukin-2, crystal structure

PDB Compounds: (L:) Fab-fragment of monoclonal antibody

SCOPe Domain Sequences for d1s5il1:

Sequence; same for both SEQRES and ATOM records:

>d1s5il1 b.1.1.1 (L:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1 [TaxId: 10090]}
dvqmtqtpltlsvtigqpasiscessqsllysngktylnwllqrpgqspkrliylvskld
sgvpdrftgsgsgtdftlrisrveaedlgvyycvqgthfprtfgggtkleik

Timeline for d1s5il1:

• d1s5il1 first appeared in SCOP 1.69
  
• d1s5il1 appears in SCOPe 2.07