Lineage for d1s5ih1 (1s5i H:1-113)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2017323Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2018168Species Mouse (Mus musculus), cluster 7.1 [TaxId:10090] [88557] (39 PDB entries)
    Uniprot P18532 # HV61_MOUSE Ig heavy chain V region 1B43 precursor
  8. 2018216Domain d1s5ih1: 1s5i H:1-113 [105272]
    Other proteins in same PDB: d1s5ih2, d1s5il1, d1s5il2
    MQ P18532 P01868 # natural 'chimera'

Details for d1s5ih1

PDB Entry: 1s5i (more details), 2.7 Å

PDB Description: Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure
PDB Compounds: (H:) Fab-fragment of monoclonal antibody

SCOPe Domain Sequences for d1s5ih1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1s5ih1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 7.1 [TaxId: 10090]}
gvqlqesgpglvkpsqslsltctvtgysitsdyawnwirqfpgnklewmgyitysgstgy
npslksrisitrdtsknqfflqlnsvttedtatyycasyddytwftywgqgtlvtvsa

SCOPe Domain Coordinates for d1s5ih1:

Click to download the PDB-style file with coordinates for d1s5ih1.
(The format of our PDB-style files is described here.)

Timeline for d1s5ih1:

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Domains from same chain:
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d1s5ih2