SCOP 1.73: Domain d1py5a_: 1py5 A:

Lineage for d1py5a_ (1py5 A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (4 PDB entries)

8. Domain d1py5a_: 1py5 A: [104389]
   complexed with py1, so4

Details for d1py5a_

PDB Entry: 1py5, 2.3 Å

PDB Description: Crystal Structure of TGF-beta receptor I kinase with inhibitor

PDB Compounds: (A:) tgf-beta receptor type I

SCOP Domain Sequences for d1py5a_:

Sequence; same for both SEQRES and ATOM records:

>d1py5a_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
tiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrheni
lgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhme
ivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkrym
apevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsve
emrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqqe
g

Timeline for d1py5a_:

• d1py5a_ first appeared in SCOP 1.69
  
• d1py5a_ appears in SCOP 1.71
  
• d1py5a_ appears in SCOP 1.75
  
• d1py5a_ appears in the current release, SCOPe 2.08