SCOP 1.73: Family d.144.1.7: Protein kinases, catalytic subunit

Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

Proteins:

1. 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [90037] (12 PDB entries)

2. Abelsone tyrosine kinase (abl) [56166] (1 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

   • Species Mouse (Mus musculus) [TaxId:10090] [56167] (8 PDB entries)

3. Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [111201] (3 PDB entries)

4. Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [90039] (7 PDB entries)

5. B-Raf kinase [103290] (1 species)
   OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

   • Species Human (Homo sapiens) [TaxId:9606] [103291] (2 PDB entries)

6. Bruton's tyrosine kinase (Btk) [75564] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [75565] (1 PDB entry)

7. c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [56138] (11 PDB entries)

8. c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

   • Species Human (Homo sapiens) [TaxId:9606] [103297] (3 PDB entries)

9. c-src tyrosine kinase [56155] (2 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

   1. Species Chicken (Gallus gallus) [TaxId:9031] [56157] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [56156] (6 PDB entries)

10. Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Rat (Rattus norvegicus) [TaxId:10116] [56121] (1 PDB entry)

11. cAMP-dependent PK, catalytic subunit [56116] (4 species)
    AGC group; PKA subfamily; serine/threonine kinase

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)

    2. Species Cow (Bos taurus) [TaxId:9913] [56118] (31 PDB entries)

    3. Species Mouse (Mus musculus) [TaxId:10090] [56119] (15 PDB entries)

    4. Species Pig (Sus scrofa) [TaxId:9823] [56117] (3 PDB entries)

12. Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56165] (2 PDB entries)

13. Casein kinase-1, CK1 [56139] (2 species)
    OPK group; CKI subfamily; serine/threonine kinase

    1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)

14. Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [64405] (27 PDB entries)

15. Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118140] (1 PDB entry)

16. Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    1. Species (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
       CDK2 homologue Pfpk5

    2. Species Human (Homo sapiens) [TaxId:9606] [88856] (124 PDB entries)

17. Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [88858] (4 PDB entries)

18. Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [88860] (8 PDB entries)

19. Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [75561] (6 PDB entries)

20. Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118138] (1 PDB entry)

21. Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118136] (1 PDB entry)

22. EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82796] (10 PDB entries)

23. epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103295] (1 PDB entry)

24. ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase

    • Species Mouse (Mus musculus) [TaxId:10090] [69828] (1 PDB entry)

25. Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56159] (4 PDB entries)

26. Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [75563] (2 PDB entries)

27. Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103299] (1 PDB entry)

28. Focal adhesion kinase 1 (fak) [103292] (1 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103293] (2 PDB entries)

29. G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase

    • Species Cow (Bos taurus) [TaxId:9913] [90035] (3 PDB entries)

30. gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [56123] (3 PDB entries)

31. Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [69824] (14 PDB entries)

32. Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56152] (4 PDB entries)

33. Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [103301] (2 PDB entries)

34. Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56163] (8 PDB entries)

35. Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [69826] (5 PDB entries)

36. Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56154] (10 PDB entries)

37. MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82790] (5 PDB entries)

38. MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [56135] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [56136] (6 PDB entries)

39. MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [56130] (41 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [56131] (3 PDB entries)

40. MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56133] (1 PDB entry)

41. Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111203] (2 PDB entries)

42. Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase

    • Species Rat (Rattus norvegicus) [TaxId:10116] [82798] (1 PDB entry)

43. Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase

    • Species Mycobacterium tuberculosis [TaxId:1773] [82794] (3 PDB entries)

44. pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56147] (2 PDB entries)

45. Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [82792] (10 PDB entries)

46. Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118130] (1 PDB entry)

47. Protein kinase CK2, alpha subunit [56142] (2 species)
    CMGC group; CK2 subfamily; serine/threonine kinase

    1. Species Human (Homo sapiens) [TaxId:9606] [75559] (3 PDB entries)

    2. Species Maize (Zea mays) [TaxId:4577] [56143] (16 PDB entries)

48. Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111197] (1 PDB entry)

49. Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118134] (4 PDB entries)

50. Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111193] (1 PDB entry)

51. Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase

    • Species Rat (Rattus norvegicus) [TaxId:10116] [118128] (3 PDB entries)

52. Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)

    • Species Human (Homo sapiens) [TaxId:9606] [143894] (1 PDB entry)

53. Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56149] (5 PDB entries)

54. Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [64407] (1 PDB entry)

55. Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56125] (1 PDB entry)

56. Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase

    1. Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)

    2. Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)

57. Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

    • Species Human (Homo sapiens) [TaxId:9606] [56145] (4 PDB entries)

58. Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111195] (3 PDB entries)

59. Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [118132] (3 PDB entries)

60. Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [111199] (1 PDB entry)

61. Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

    • Species Human (Homo sapiens) [TaxId:9606] [56161] (3 PDB entries)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit:

• Family d.144.1.7: Protein kinases, catalytic subunit first appeared in SCOP 1.65
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in SCOP 1.71
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in SCOP 1.75
  
• Family d.144.1.7: Protein kinases, catalytic subunit appears in the current release, SCOPe 2.08